Effect of ethanol in single dose on liver of ethanol-treated and nontreated mice

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Abstract
The effect of a single large dose of subcutaneously administered ethanol on the liver weights, alcohol dehydrogenase (ADH), glycogen, and total lipids was investigated at various time intervals in male mice that had been pretreated with ethanol or were previously untreated. The single large dose of ethanol elicited a pronounced increase in total liver lipids and a pronounced decrease in total liver glycogen of both the ethanol-pretreated and the nonpretreated mice. Generally, the total liver ADH of the nonpretreated mice was elevated. There were no changes in the liver weights. Sixteen hours after ethanol administration, the total liver glycogen and total liver lipids of the normal mice and the total liver lipids of the ethanol-pretreated mice had not returned to the preinjection levels.

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