Effect of the chemosterilant apholate on the synthesis of cellular components in developing housefly eggs

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Abstract
After an initial lag period, the DNA content in normal housefly eggs increases rapidly during incubation at 37[degree], whereas the RNA content remains almost constant. The synthesis of lactate dehydrogenase in normal eggs parallels the synthesis of DNA during incubation. However, the activity of glucose 6-phosphate dehydrogenase in the eggs remains unchanged during the same period. Non-viable eggs deposited by insects given a diet treated with the chemosterilant apholate do not synthesize any significant quantities of DNA during incubation. The absence of DNA synthesis in the non-viable eggs deposited by flies given apholate is accompanied by the loss of the ability of the eggs to form lactate dehydrogenase. On the other hand, the enzyme glucose 6-phosphate dehydrogenase is unaffected.