Effect of Vitamin B6 and B1 Deficiencies on the Intestinal Uptake of Calcium, Zinc and Cadmium

Abstract
A chronic vitamin B6 deficiency in rats resulted in a nonspecific increase (44-51%) in the in vitro intestinal uptake of both essential (Ca and Zn) and nonessential toxic metal (Cd) ions, while an acute B6-deficient state only affected the Zn uptake rate. In vitamin B1-deficient animals, a specific decrease (30-32%) was observed in Ca and Zn uptake with a 59% increase in the intestinal uptake of Cd. These altered metal ion uptake rates were probably not a result of hormonal disturbances due to the vitamin-deficient states.

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