Effect of the Protein Content of the Diet on the Glomerular Filtration Rate of Young and Adult Rats

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Abstract
Inulin clearances were estimated (a) in adolescent rats weighing from 101 to 150 gs., and (b) in adult rats weighing from 275 to 320 gs. They were fed on a diet containing varying atnts. of casein. In both adolescent and adult rats fed on a diet low in casein, the rate of glomerular filtration was correlated with that of the urine flow. In adult rats fed on a diet containing at least 18% casein, the rate of glomerular filtration was independent of the urine flow. Raising the amt. of casein in the food, and thus the plasma protein level, produced an increase in the rate of glomerular filtration.

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