Reaction of Oxiranes with Dianions of Secondary Amides. New Entry to 5-Alkylsubstituted γ-LACTAMS
- 1 July 1988
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 18 (10) , 1159-1165
- https://doi.org/10.1080/00397918808060903
Abstract
The oxirane ring cleavage with dilithiated secondary amides was accelerated by the addition of boron trifluoride-etherate to afford γ-hydroxyamides, which were transformed into 5-alkylsubstituted γ-lactams via an intramolecular N-alkylation reaction.Keywords
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