Course of Parabiotic Hypertension Following Total Adrenalectomy

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Abstract
Hypertension which develops spontaneously in one of the partners when rats are joined in parabiosis is abolished by adrenalectomy of the hypertensive rat. Adrenalectomy of the normotensive member of pairs in which one partner is normotensive and the other hypertensive does not affect significantly the blood pressure of the latter. The immediate post-operative decline in the blood pressure of the hypertensive parabiont following adrenalectomy fails to progress, and a return to hypertensive levels is observed, when there occurs regeneration of cortical tissue from a residuum overlooked at operation. It is concluded that the adrenal either participates in the production of a pressor substance or is necessary for maintaining cardiovascular response to such an agent.