Platelet antigen allele frequencies in Australian Aboriginal and Caucasian populations
- 1 January 1997
- Vol. 29 (4) , 392-398
- https://doi.org/10.1080/00313029700169375
Abstract
Summary We have applied genotyping methods of PCR-SSOP and PCR-RFLP to three, bi-allelic platelet specific antigen systems HPA-1 (Pla), HPA-3 (Bak) and HPA-5 (Br). This combination of techniques offers flexibility for high volume or rapid typing. The phenotype and genotype frequencies of alleles from the three systems differ significantly between the Yuendumu Australian Aboriginals (Wailbri) and Australian Caucasians. The major differences are the very tow frequencies of HPA-lb and HPA-3b in Yuendumu Aboriginals which are potentially relevant to platelet transfusion in patients of Australian Aboriginal descent.Keywords
This publication has 16 references indexed in Scilit:
- Genomic RFLP typing of human platelet alloantigens Zw(PlA), Ko, Bak and Br (HPA‐1, 2, 3, 5)British Journal of Haematology, 1995
- Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele‐specific primersTransfusion, 1994
- The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2).Journal of Clinical Investigation, 1993
- HPA‐1 typing by PCR amplification with sequence‐specific primers (PCR‐SSP): a rapid and simple techniqueBritish Journal of Haematology, 1993
- Determination of human platelet antigen frequencies in the Dutch population by immunophenotyping and DNA (allele-specific restriction enzyme) analysisBlood, 1993
- Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele- specific oligonucleotide probesBlood, 1991
- Posttransfusion purpura due to an alloantibody reactive with glycoprotein Ia/IIa (anti-HPA-5b)Blood, 1991
- Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen systemBlood, 1990
- The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.Journal of Clinical Investigation, 1989
- 348 CASES OF SUSPECTED NEONATAL ALLOIMMUNE THROMBOCYTOPENIAThe Lancet, 1989