Immunogenetics of the Lennox‐Gastaut Syndrome: Frequency of HL‐A Antigens and Haplotypes in Patients and First‐Degree Relatives

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Abstract
Patients (22) with the Lennox-Gastaut syndrome and their families were examined for HL-A antigens by the microlymphocytotoxicity test. The antigen HL-A7 belonging to the HL-A locus showed a significantly increased frequency (P < 0.0005) in parents and in patients. The same antigen showed a significantly altered segregation in patients, but a normal one in healthy siblings. Another antigen of the 2nd HL-A locus, HL-A12, did not display a normal segregation in the patients, in whom it was barely represented.