Furazolidone concentrations in plasma, milk and some tissues of Nubian goats

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Abstract
The concentrations of furazolidone (FZ) in plasma and milk were measured in goats treated orally with the drug at a dose of 10 mg/kg daily for 5 days. The maximum plasma concentrations obtained were 1.57 .+-. 0.52 .mu.g/ml (n = 5) 8 h after the 1st dose, and 2.13 .+-. 0.11 .mu.g/ml (n = 4) 6 h after the 5th dose. The maximum milk concentration was 0.88 .+-. 0.32 .mu.g/ml (n = 4) 8 h following the administration of a single dose. Using a colorimetric method, FZ was not detectable in goats'' liver or muscle after the recommended therapeutic dose (10 mg/kg, 5 days). Using an HPLC [high performance liquid chromatography] method, the drug was detected 24 h after the treatment in the gluteal muscle and liver at concentrations of 0.26 .+-. 0.01 .mu.g/g (n = 5) and 0.10 .+-. 0.02 .mu.g/g (n = 5), respectively. The drug concentrations decreased significantly (P < 0.05-0.01) at 3, 5 and 7 days after treatment, and no measurable concentrations were found after 10 days.