Chemical Heterogeneity of Foetal Haemoglobin in the Lepore Haemoglobinopathy
- 1 June 1974
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 27 (2) , 319-329
- https://doi.org/10.1111/j.1365-2141.1974.tb06799.x
Abstract
Summary. The glycine/alanine composition of the γCB‐3 peptide of haemoglobin F obtained from persons heterozygous and homozygous for haemoglobin Lepore has been determined. The mean glycine value for heterozygotes was 0.34 ± 0.1 residues which is similar to that observed in the haemoglobin F of normal adults. A higher glycine value was found in a homozygous individual. These findings are discussed with regard to the light which they shed on the molecular basis for the haemoglobin‐Lepore disorders and related types of δβ and β thalassaemia.This publication has 36 references indexed in Scilit:
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