THE ACUTE EFFECT OF SALTS ON THE URINARY EXCRETION OF RADIOIODIDE IN MICE1

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Abstract
The acute effect of various ions on the urinary excretion of radioiodinc was investigated by measuring the radioiodine excretion in the urine of mice injected with I131 subcutaneously and given 0.517 milliequivalent of various salts through the gastric route. Sodium, potassium, rubidium, chloride, bromide, iodide ions increased the excretion of radioiodine, while lithium, calcium, ammonium, carbonate and acetate ions did not. Glucose and water had no effect. Since only those salts releasing one or more highly dissociated ions did increase the excretion of radioiodine, this effect appears to be due to an increased concentration of ions in the body.