Thyroidal I131 Collection in Normal and Adrenalectomized Rats, Effect of Desoxycorticosterone Acetate and Physiological Saline.

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Abstract
Adrenalectomized male rats, fed an I deficient diet and maintained on 1/4 mg desoxycorticosterone acetate (DCA) daily, were injected intravenously with I131 containing 8.5 [mu]g of iodide carrier. Thyroidal collection of I131 increased at 3 hours (hr.) after 1.25 mg DCA/100 g, but not at 1.5 hr after 1.5 mg DCA/100 g, the DCA being given intraperitoneally immediately after I131 in both groups. There was no change from controls in plasma I131 level or urinary Il31 excretion. Under similar conditions, adrenalectomized rats showed increased thyroidal I131 collection 3 hr. and 1.5 hr. after intra-peritoneal injection of 10 ml 0.9% NaCl/100 g. This occurred despite decreased plasma radioactivity and increased urinary Il31 excretion. Intact rats studied under the same conditions showed no change from controls in thyroidal I131 collection, but had less radioactivity in their blood plasma.