Lithium treatment and glucose tolerance in manic-melancholic patients

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Abstract
I.v. glucose tolerance was measured in manic-melancholic patients given 1 daily Li-dose for relapse prevention. Glucose tolerance was increased for some h after each Li administration. In the 1st wk of treatment glucose disposal rate was increased up to 12 h after Li ingestion. In long-term treated patients glucose tolerance was increased 2 h after administration but not 12 h after. Fasting glucose was increased 2 h after Li administration in long-term treated patients. Concomitant changes in lactate, triglycerides, free-glycerol and electrolytes were measured in serum.