Synthesis of the Trisaccharide Repeating Unit of the K-Antigen from Klebsiella Type-63
- 1 December 1997
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 16 (9) , 1363-1371
- https://doi.org/10.1080/07328309708005755
Abstract
The benzyl substituted ethyl thioglycoside of L-fucose was found to be a more reactive donor compared to 2-O-benzyl substituted p-tolyl thioglycoside of D-galactose. Using the benzyl substituted ethyl thioglycoside of L-fucose (8), as a donor and the suitably substituted p-tolyl thioglycoside of D-galactose (7) as acceptor, the p-tolyl thioglycoside of the disaccharide, 9, was prepared. This disaccharide donor was allowed to react with a suitably protected galactopyranosyluronic acid acceptor, 16, to give the trisaccharide repeating unit of the K-antigen from Klebsiella type 63.Keywords
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