Long-term Efficacy of BCG Vaccine in American Indians and Alaska Natives
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Open Access
- 5 May 2004
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 291 (17) , 2086-2091
- https://doi.org/10.1001/jama.291.17.2086
Abstract
Bacille Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis that is used worldwide as a tuberculosis vaccine. Although the reported efficacy of BCG vaccines in controlled trials varies greatly, a meta-analysis found that overall, the vaccine reduced the risk of tuberculosis by 50% but that the duration of the protective effect could not be quantified.1 A meta-analysis of efficacy over time among randomized controlled trials reported a 5% to 14% annual decrease among 7 trials and an increase in efficacy of up to 18% among 3 others.2Keywords
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