EFFECTS OF PRIMAQUINE ON THE RED BLOOD CELL MEMBRANE. II. K+ PERMEABILITY IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENT ERYTHROCYTES*
Open Access
- 1 January 1961
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 40 (1) , 140-143
- https://doi.org/10.1172/jci104227
Abstract
"Primaquine-sensitive" erythrocytes, having a deficient activity in glucose-6-phosphate dehydrogenase, demonstrate an in vitro prelytic loss of K+ identical to that of normal cells when both are exposed to primaquine or serum containing primaquine metabolites. These results emphasize the importance of in vivo removal mechanisms in the hemolytic anemia induced by primaquine and related compounds.Keywords
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