A biomimetic and fully regiocontrolled total synthesis of (±)-colchicine
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 14,p. 974-975
- https://doi.org/10.1039/c39920000974
Abstract
The first fully regiocontrolled total synthesis of the alkaloid colchicine 1 is described; the key step of the reaction sequence is the efficient biomimetic conversion of the σ-homo-o-benzoquinone monoacetal 11 into the α-tropolone-O-methyl ether 13.Keywords
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