Effects of Lipoid A Component of Escherichia coli Endotoxin on Dermal Reactivity of Rabbits to Epinephrine.

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Abstract
The purified and polysaccharide-free lipoid A component of E. coli 0111B4 endotoxin, upon intravenous in-jection into rabbits, strikingly alters dermal reactivity to epinephrine. Grossly, the lesions thus produced are red or brownish in appearance or show marked hemorrhages. Lipoid A is aetive in amounts as small as 2 ug/kg. The original lipopolysaccharide is approximately 10 times more potent than the lipoid A fraction obtained therefrom. Phen-oxybenzamine hydrochloride inhibits the epinephrine reaction in rabbits injected with lipoid A.