GLUCOSE TOLERANCE IN RATS FOLLOWING REPEATED SMALL DOSES OF ALLOXAN

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Abstract
Rats given 14 sub-diabetogenic doses of alloxan over a period of 4 wks. did not become hyperglycemic on the normal diet, but showed impaired tolerance to administered glucose. The decrease in tolerance to glucose appeared to be permanent since it remained for 231/2 wks. after cessation of alloxan treatment. In a 2d group of rats there was a marked and progressive decrease in glucose tolerance after each injn. of a 25 mg./kg. dose of alloxan. The decrease in glucose tolerance was shown by the higher blood glucose levels reached early in the tests, and in the slower return of the glucose levels to normal. It was concluded that 25 mg./kg. doses of alloxan given intravenously produced a progressive damage to pancreatic islets in rats, and that even the small amt. of damage was not followed by a compensatory mechanism. Ant. pituitary extract administered to 4 rats with impaired glucose tolerance produced hyperglycemia, after 11 days, in 3 of 4 animals.[long dash]Authors.

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