Effect of Drynaria baronii Rhizome Extracts on the Proliferation in Osteoblast-Like UMR106 Cells

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Abstract
Cultured osteoblast-like UMR106 cells were employed as an osteoblast model and the effect of Drynaria baronii rhizome extracts on cell proliferation was studied. The crude ethanol extract of Drynaria baronii promoted cell proliferation by 36% at a concentration of 0.4 mg/ml after 36 hours co-culturing with UMR106 cells, which was similar to that of 10 -5 mol/L NaF. Both its ethyl acetate fraction and n -butanol fraction partitioned from the crude extract were found the same promoting effect as the crude extract, and the effective concentration of the n -butanol fraction was lower than that of the crude extract. The residual aqueous fraction had no significant effect on the cell proliferation. The results suggested that Drynaria baronii rhizome extracts might have potential activity against osteoporosis, and that its ethyl acetate and n -butanol fractions might contain active constituents stimulating osteoblasts.