PSEUDOLEUKEMIA - INEFFECTIVE REGULATION OF GRANULOPOIESIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 105  (3) , 122-125
Abstract
A neonate with Down''s syndrome confirmed by chromosomal analysis had leukocytosis with a WBC [white blood cell] count of 48,000/mm3 at age 13 days. Differential counts showed 70-90% blast forms by light microscopy. The blast-cell granules stained negatively with Sudan black B and .alpha.-napthyl butyrate esterase. Myeloperoxidase activity evaluated by light and EM was negative. The granules stained positively with PAS [periodic acid Schiff], .beta.-glucoronidase and tartrate-sensitive acid phosphatase. Indirect immunofluorescence for terminal-deoxynucleotidyl transferase was negative. The blast cells of pseudoleukemia may be of lymphoid origin.

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