New synthetic routes to protected purine 2′-O-methylriboside-3′-O-phosphoramidites using a novel alkylation procedure
Open Access
- 11 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 18 (1) , 41-49
- https://doi.org/10.1093/nar/18.1.41
Abstract
A highly selective alkylation procedure has been developed enabling new synthetic routes to be established for protected purine 2′-O-methylriboside- 3′-O-phosphoramidites; building blocks for the assembly of 2′-O-methyloligoribonucleotides. The new procedure avoids the use of the highly toxic and potentially explosive reagent diazomethane and is far superior to the use of silver oxide/methyl iodide. Moreover, the use of highly versatile key intermediates will enable the synthesis of a wide variety of base modified analogues as well as other 2′-O-alkylriboside derivatives.This publication has 20 references indexed in Scilit:
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