THE RELATION OF ADRENALINE TO ACETYLCHOLINE IN THE NERVOUS SYSTEM

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Abstract
"The evidence which has been summarised in the (present) review indicates that acetylcholine and adrenaline in the nervous system have a different relationship from that existing elsewhere. Whereas in the heart, the viscera and throughout the tissues innervated by the autonomic system these 2 substances have actions which are antagonistic, in the nervous system on the other hand, adrenaline, having little action of its own, exerts a powerful influence in modifying the action of acetylcholine. In general it can be said that in low concns. adrenaline augments the effect of acetylcholine, wnile in higher conens. it depresses it." Evidence of this action has been obtained at anterior horn cells, along the course of nerves, at neuromuscular junctions, and in sympa- thetic ganglia. The basis of the potentiation is discussed. 46 references.