STUDIES ON THE EFFECT OF SOME AROMATIC AMIDINES AND OTHER CHEMICAL COMPOUNDS ON THE GROWTH OF INFLUENZA VIRUS IN THE EMBRYONATED EGG

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Abstract
The effect of chemicals and biological substances on the growth of influenza virus in the embryonated egg is of interest as a fundamental study and as a means of screening substances for their possible chemotherapeutic activities. This work was done to investigate the activity of some heretofore unreported substances. Most chemicals proved to have no effect on the growth of influenza virus in the developing egg, but one group, the aromatic amidines, and hexamidine in particular, was found to possess some inhibitory action. It was an in vivo rather than an in vitro effect; it was dependent on the route of inoculation and the amount of drug administered; and the activity was exhibited when the introduction of the drug was delayed for as long as 16 hr. after inoculation of the eggs with influenza virus. Preliminary tests have failed to demonstrate any protection of mice infected with influenza and treated with hexamidine.