BRAIN‐SPECIFIC ANTIGENS IN THE QUAKING MOUSE DURING ONTOGENY

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Abstract
Abstract— By means of crossed Immunoelectrophoresis the concentrations of 7 brain‐specific antigens have been investigated during the ontogenic development of normal and Quaking mice. Two proteins, the glial fibrillary acidic protein and the brain‐specific membrane protein D5 were found to be strongly increased in mutant brains. The synaptosomal antigen synaptin (Cl), the 14‐3‐2 protein of neuronal cytoplasm, and the neuronal membrane antigens D1, D2 and D3 were all present at normal levels in mutant brains.