Studies on Compensatory Renal Hypertrophy. I. Effect of Unilateral Ureteral Ligation and Transection.

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Abstract
Summary Data are presented comparing the relative rate of compensatory renal hypertrophy and hyperplasia of the control kidney of rats following either unilateral ureteral transection, ligation, or nephrectomy. The growth of the control kidney on the unoperated side was strikingly slower after ureteral transection and ligation when compared with that resulting from the removal of one kidney. Progressive hydronephrosis was observed on the operated side following ureteral transection and ligation and was more pronounced in the latter. Degree of hypertrophy of the control kidney showed a close correlation with degree and duration of the hydronephrosis of the kidney on the operated side. These observations have been interpreted as indicating the operation of a control system regulating kidney growth in response to changes in some way related to kidney size.

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