Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells.

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Abstract
A xenogeneic antiserum raised to anti-reovirus Ig was used to define an idiotypic determinant present on antibodies to reovirus type 3 hemagglutinin. The same idiotype was identified on nonimmune lymphoid cells and on neuronal cells that specifically bind the hemagglutinin of type 3 reovirus. This idiotypic determinant, called Id3, is shared by a monoclonal antibody to the neutralization site of hemagglutinin from type 3 reovirus, BALB/c serum antibodies to the hemagglutinin of reovirus type 3, R1.1, a murine thymoma cell line that binds reovirus type 3 and primary cultures of murine neuronal cells. The presence of an idiotype shared by antihemagglutinin antibodies and by structures on nonlymphoid cells suggests a general relationship between disparate receptors that recognize a common determinant. This suggests a novel approach for the study of viral receptor interactions and for analysis of mechanisms of [post-viral infection] autoimmune responses.