Interferon inhibits the generation of allospecific suppressor T lymphocytes.
Open Access
- 1 June 1982
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 155 (6) , 1610-1622
- https://doi.org/10.1084/jem.155.6.1610
Abstract
The effect of human interferon .alpha. on the differentiation of functional populations of lymphocytes during the human allogeneic response in vitro was studied. Interferon .alpha. inhibited the generation of allospecific suppressor T lymphocytes that normally develop from lymphocytes primed in vitro against allogeneic cells. This effect was not the result of the destruction by interferon of precursor suppressor cells but rather to inhibition of their differentiation into active suppressor T lymphocytes. This inhibition was reversible and could be overcome by repeated allogeneic stimulation even in the presence of interferon. Inhibition of the generation of allospecific suppressor lymphocytes by interferon might play an important role in the allogeneic response. Interferon inhibited the proliferation of lymphocytes after allogeneic stimulation in a primzry mixed lymphocyte reaction but enhanced their cytotoxicity. Despite the inhibitory effect in the primary mixed lymphocyte reaction, the specific secondary proliferative response of lymphocytes primed against a single HLA-DR antigen was only slightly affected by interferon. The nonspecific secondary proliferative response of lymphocytes primed in the presence of interferon was significantly reduced, indicating that interferon might decrease the recruitment of nonspecific irrelevant clones of responding cells during the sensitization period.This publication has 21 references indexed in Scilit:
- Cloning and Characterization of Primary Alloreactive Human T-LymphocytesImmunological Reviews, 1981
- Cloned Cytotoxic and Non‐Cytotoxic Lymphocytes in Mouse and Man: Their Reactivities and a Large Cell Surface Membrane Protein (LMP) Differentiation Marker SystemImmunological Reviews, 1981
- Retention of specific proliferative capacity of cloned human T cells alloactivated againstHLA-D allelesImmunogenetics, 1980
- Human Leucocyte Interferon: Analysis of Effect on MLC and Effector Cell GenerationScandinavian Journal of Immunology, 1979
- Standardization of the Human in vitro Cell‐mediated Lympholysis TechniqueTissue Antigens, 1979
- Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.The Journal of Experimental Medicine, 1979
- HLA-DR specific human suppressor lymphocytes generated by repeated in vitro sensitisation against allogeneic cellsNature, 1978
- Cellular origin of cytotoxic effectors and secondary educated lymphocytes in human mixed leukocyte reactionCellular Immunology, 1977
- HL-A LD (Lymphocyte Defined) Typing: A Rapid Assay with Primed LymphocytesScience, 1975
- Mixed lymphocyte reactivity of human lymphocytes primed in vitro. I. Secondary response to allogenic lymphocytesEuropean Journal of Immunology, 1975