THE EHRLICH ASCITES CARCINOMA AS A TOOL FOR THE RAPID EVALUATION OF THE EFFICACY OF RADIOPROTECTIVE COMPOUNDS AT THE CELLULAR LEVEL

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Abstract
A simple, rapid quantitative method for biologically evaluating radioprotective compounds at the cellular level has been developed by means of Ehrlich mouse ascites tumor cells. The cells were irradiated in vitro and subsequently grown in vivo and the radioprotective compound was evaluated by its ability to prevent mitotic arrest and loss of proliferative capacity in the cells. Results statistically significant at the 1% level were available in 48 hours when groups of 15 mice per sample were compared. L-Cysteine was found to be a better protector than 2-aminoethylisothiouronium bromide hydrobomide or 2-mercaptoethylamine and also increased the protection of cells irradiated under anaerobic conditions.