Combretastatin A4 Phosphate Has Tumor Antivascular Activity in Rat and Man as Demonstrated by Dynamic Magnetic Resonance Imaging
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- 1 August 2003
- journal article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 21 (15) , 2831-2842
- https://doi.org/10.1200/jco.2003.05.187
Abstract
Purpose: Combretastatin A4 phosphate (CA4P) is a novel vascular targeting agent. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) studies were performed to examine changes in parameters related to blood flow and vascular permeability in tumor and normal tissue after CA4P treatment.Keywords
This publication has 45 references indexed in Scilit:
- Assessment of Pharmacodynamic Vascular Response in a Phase I Trial of Combretastatin A4 PhosphateJournal of Clinical Oncology, 2003
- Phase I Clinical Trial of Weekly Combretastatin A4 Phosphate: Clinical and Pharmacokinetic ResultsJournal of Clinical Oncology, 2003
- The vascular response of tumor and normal tissues in the rat to the vascular targeting agent, combretastatin A-4-phosphate, at clinically relevant doses.International Journal of Oncology, 2002
- Dynamic contrast‐enhanced MRI in clinical oncology: Current status and future directionsJournal of Magnetic Resonance Imaging, 2002
- Estimating kinetic parameters from dynamic contrast-enhanced t1-weighted MRI of a diffusable tracer: Standardized quantities and symbolsJournal of Magnetic Resonance Imaging, 1999
- MR microcirculation assessment in cervical cancer: Correlations with histomorphological tumor markers and clinical outcomeJournal of Magnetic Resonance Imaging, 1999
- Evaluation of chemotherapy in advanced urinary bladder cancer with fast dynamic contrast-enhanced MR imaging.Radiology, 1998
- Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4Cellular and Molecular Life Sciences, 1989
- Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulinBiochemical Pharmacology, 1983
- Isolation and structure of combretastatinCanadian Journal of Chemistry, 1982