A life table for onset of Huntington's chorea
- 1 October 1981
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 45 (4) , 375-385
- https://doi.org/10.1111/j.1469-1809.1981.tb00351.x
Abstract
Accurate quantitative assessment of risk in Huntington's chorea necessitates unbiased estimation of the distribution of age at onset. Previous studies have quoted the mean observed age at onset but this is biased, containing on contribution from heterozygotes who have not manifested, which takes due account of such censored heterozygotes; it demonstrates a considerably older median age onset than hitherto been reported.Keywords
This publication has 6 references indexed in Scilit:
- Factors influencing age at onset and duration of survival in Huntington's choreaAnnals of Human Genetics, 1981
- Huntington's Chorea in South Wales A genetic and epidemiological studyClinical Genetics, 1981
- HUNTINGTON'S CHOREA The Basis for Long-Term PreventionThe Lancet, 1979
- Ascertainment in the sequential sampling of pedigreesClinical Genetics, 1977
- Age-at-onset distribution in chronic diseases. A life table approach to analysis of family dataJournal of Chronic Diseases, 1973
- The relation of type of initial symptoms and line of transmission to ages at onset and death in Huntington's diseaseClinical Genetics, 1971