Alkaline Phosphatase Activity of Healing Gingival Wounds in the Rat

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Abstract
Experimental wounds of the gingiva of the rat show a marked augmentation of alkaline phosphatase activity in the outer layers of epithelium adjacent to the incision and in and surrounding the organizing fibrin clot in the lamina propria. The increased enzymatic activity in the region of the healing wound appears to be associated with the growth and function of outgrowing capillaries, the activity of fibroblasts in connection with the development of connective tissue fibers, the activity of macrophages within and around the lesion, and keratinization proceeding from the margins of the epithelial cicatrix.