STUDIES IN EPILEPSY

Publisher Website
Google Scholar
Abstract
The mechanism by which certain drugs produce convulsions in normal animals presumably differs from the mechanism involved in spontaneous convulsions in persons. Nevertheless, it seems worth while to inquire to what extent factors which are known to modify convulsions in patients have a similar effect on convulsions experimentally induced in animals. For these experiments, eighty-seven rabbits were used. Two convulsants were employed, thujone, made from oil of wormwood, and homocamfin, a preparation of camphor suitable for intramuscular injection in man. Thujone has been used recently by Uyematsu and Cobb,1 Elsberg, Stookey and Pike,2 Dandy,3 Florey,4 Sparks,5 Muncie and Schneider6 and by others. The method of judging results is important. Most of the authors named found for each animal the minimum amount of the convulsant which would induce a convulsion under normal and experimental conditions. In such a method it is assumed that the reaction

This publication has 2 references indexed in Scilit: