THE RELATIVE INFLUENCE OF DIELECTRIC AND OTHER DRYING TECHNIQUES ON THE PHYSICO - MECHANICAL PROPERTIES OF A PHARMACEUTICAL TABLET EXCIPIENT. PARTI: COMPACTION CHARACTERISTICS.

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Abstract
The relative Influence of nine techniques for drying wet granulated microcrystal-lline cellulose (MCC) on the subsequent compaction characteristics was studied In terms of the tensile strength and corrected work of failure of the tablets. Wet granulation resulted in a substantial decrease in compatibility. However, the drying technique used was found to affect the degree of loss in compatibility. In general, microwave-vacuum drying using the “high” process type resulted in the production of granules with the highest compatibility followed by freeze drying and fluidized bed drying. Granules dried under ambient conditions, and granules tray dried to “just dry” or “over dried” conditions resulted In tablets possessing approximately comparable compatibilites, with the poorest compaction characteristics being exhibited by vacuum dried granules, in addition It was found that use of a “low” drying process type during microwave- vacuum drying yielded granules with inferior compaction characteristics to those dried by the “high” process type. Radio frequency drying was found to yield granules which produced tablets having slightly inferior tensile strength to tray dried material, although the tablet work of failure values were comparable. The effect of drying technique on the subsequent compaction characteristics was not found to be directly related to the moisture content of the granules.

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