A membrane vesicle/ribosome preparation fromSerratia marcescens elicits peritoneal exudate cells expressing both tumoricidal and bactericidal activity

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Abstract
A biological response modifier called ImuVert, derived from the bacteriumSerratia marcescens, produced long-lasting elevation of peritoneal excludate cell (PEC) numbers after intraperitoneal injection into mice. These cells had enhanced ability to phagocytose both latex beads and opsonizedListeria monocytogenes. PEC harvested 2–14 days after a single injection of ImuVert killedL. monocytogenes, and ImuVert protected mice from infection byL. monocytogenes, measured both by LD50 and bacterial growth in vivo. Cells harvested 7 and 14 days after ImuVert injection also were tumoricidal, measured as killing of P815 mastocytoma cells, and ImuVert induced macrophages to express tumoricidal properties in vitro. These data suggest that ImuVert has a unique ability to induce a chronic inflammatory response, as other agents do not induce such a long-lasting influx of bactericidal inflammatory cells that also show tumoricidal activity. The consequences of this response appear to include protection from infection by certain bacteria.