CIRCULATING IMMUNE COMPLEXES IN TAKAYASU DISEASE

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Abstract
Circulating immune complexes in Takayasu disease were investigated to assess the involvement of autoimmune mechanisms. The 10% inhibition of ADCC [antibody-dependent cell-mediated cytotoxicity] in 37 patients was 35.6 .+-. 5.2, this being a non-statistically significant value as compared with the value of 25.6 .+-. 3.0 in 33 apparently healthy controls. Raji [human Burkitt''s lymphoma] cell assay values were 30.4 .+-. 11.5 and 3.5 .+-. 2.3 for patients and controls, respectively. As 54% of all patients had a negative reaction and there was no correlation between immune complex levels and BSR [blood sedimentation rate], CRP [C-reactive protein] or ASO [anti-streptolysin O level], immune complexes, while accelerating or modifying the pathophysiological state, probably are not primary causative factors.