Review article: the histamine H3‐receptor: a novel prejunctional receptor regulating gastrointestinal function

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Abstract
SUMMARY: This review examines the evidence for the existence in the gastrointestinal tract of a new subtype (H3) of histamine receptors, previously described in the central nervous system. Study of these receptors is facilitated by the availability of the highly selective agonist (R)α‐methylhistamine and the selective antagonist, thioperamide. H3‐receptors seem to exert negative control on gastric acid secretion evoked by indirect cholinergic stimuli: their localization is unclear but it seems to be outside the parietal cell. H3‐receptors also seem to be located on cholinergic and non‐adrenergic non‐cholinergic (NANC) neurones of the myenteric plexus, where they negatively control the release of neurotransmitters.