Steady-state moxalactam kinetics: Comparisons with other cephalosporins

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Abstract
Moxalactam is a new beta-lactam antimicrobial with an extended spectrum. Serum concentrations were determined in 14 patients at steady state using bioassay and high-pressure liquid chromatography methods. Mean peak and trough serum concentrations were 195 and 29.5 .mu.g/ml for the 2 g dose and 214 and 28.8 .mu.g/ml for the 3 g dose. Peak and trough levels exceeded the minimum inhibitory concentration of the infecting bacteria in 100% and 67% of the patients. The 3 g dose is recommended for infections caused by Pseudomonas aeruginosa and other organisms with higher minimum inhibitory concentrations. Half-lives ranged from 1.7-5.7 h and reflected the varying renal functions of the patients. A relationship (r = 0.878, P < 0.01) between creatinine clearance and elimination rate constant was established by bivariant linear regression analysis.