NORMAL CANINE EXCRETORY UROGRAM - EFFECTS OF DOSE, TIME, AND INDIVIDUAL-DOG VARIATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (11) , 1596-1604
Abstract
Healthy, young, adult mongrel dogs [10] were given sodium iothalamate at dose levels of 200, 400 and 800 mg of I/0.45 kg of body wt on separate occasions by rapid i.v. injection; urinary bladders of the dogs were empty before injections were begun. Of the 10 dogs 7 were given an additional dose of sodium iothalamate (400 mg of iodine/0.45 kg) with the bladder partially distended with sterilized saline solution. Ventrodorsal abdominal radiographs were obtained immediately and at 5, 10, 20, 40, 60, and 120 min after injection of contrast medium. The kidneys, renal pelves, pelvic diverticula and ureters were evaluated for radiographic density (radiopacity). The lengths and widths of the kidneys, pelves and diverticula and the width of the ureters were determined and those measurements were standardized by dividing the values by the corresponding length of the 2nd lumbar vertebral body. Post-injection radiographs should be obtained immediately and at 5, 20 and 40 min. The optimal dose of contrast medium was 400 mg of iodine/0.45 kg body wt. The dose of contrast medium, as well as the time of postinjection radiography, significantly influenced many of the measurements (both linear and density) in the excretory urogram of normal dogs. Values for the measurements of urinary structures are also presented.