Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
Top Cited Papers
- 6 April 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5514) , 104-106
- https://doi.org/10.1126/science.1057991
Abstract
The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chicoextends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype ofchico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.Keywords
This publication has 21 references indexed in Scilit:
- A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine FunctionScience, 2001
- Genetic pathways that regulate ageing in model organismsNature, 2000
- IRS-2 pathways integrate female reproduction and energy homeostasisNature, 2000
- Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice1Endocrinology, 2000
- A Delayed Wave of Death from Reproduction in DrosophilaScience, 1999
- Dwarf mice and the ageing processNature, 1996
- Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.Proceedings of the National Academy of Sciences, 1996
- The Drosophila insulin receptor is required for normal growth.Endocrinology, 1996
- The ovo locus is required for sex-specific germ line maintenance in Drosophila.Genes & Development, 1987
- Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacityActa Endocrinologica, 1984