Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus

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Abstract
A series of 55 salicylamides, including 3,5-dibromo-, 5-n-alkyl- and 5-n-acylsalicyloyl derivatives of various anilines, heterocyclic amines, benzylamines and alkylamines, was synthesized and evaluated for in vitro antiantibacterial activity against A. viscosus, an adherent oral microorganism implicated in periodontal disease. The in vitro minimum inhibitory concentrations of 15 4''-bromosalicylanilides correlated (r = 0.92) with estimated log D values. Several nonhalogenated salicylanilides, such as 5-n-hexyl- and 5-n-decanoyl-4''-nitrosalicylanilide, exhibit higher levels of in vitro antibacterial activity against a number of Actinomycetes than did tribomsalan or fluorophene.