The Serpin Inhibitory Mechanism Is Critically Dependent on the Length of the Reactive Center Loop
Open Access
- 1 July 2001
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 276 (29) , 27541-27547
- https://doi.org/10.1074/jbc.m102594200
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- A serpin‐induced extensive proteolytic susceptibility of urokinase‐type plasminogen activator implicates distortion of the proteinase substrate‐binding pocket and oxyanion hole in the serpin inhibitory mechanismEuropean Journal of Biochemistry, 2001
- Structure of a serpin–protease complex shows inhibition by deformationNature, 2000
- What can the structures of enzyme-inhibitor complexes tell us about the structures of enzyme substrate complexes?Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000
- Structural Change in α-Chymotrypsin Induced by Complexation with α1-Antichymotrypsin As Seen by Enhanced Sensitivity to ProteolysisBiochemistry, 1996
- Trypsin complexed with α1‐proteinase inhibitor has an increased structural flexibilityFEBS Letters, 1995
- Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrateBiochemistry, 1991
- Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpinsBiochemistry, 1989
- Genomic and cDNA cloning of the human C1 inhibitorEuropean Journal of Biochemistry, 1988
- Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases.Proceedings of the National Academy of Sciences, 1986
- Structural basis of the activation and action of trypsinAccounts of Chemical Research, 1978