Multiple Deficiencies in the Modified Goldberger Diet as Demonstrated with Chicks

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Abstract
The limitations of the modified Goldberger ration have been determined with the aid of chicks and supplementation with various vitamins. Thiamin exerts no effect on growth, but riboflavin has been shown to give definite growth responses. Nicotinic acid was found to give variable responses in growth at levels below 20 mg. per 100 gm. of ration. Vitamin B6 alone did not increase growth over the basal, but when added to a liver fraction which furnished additional factors, a definite response was obtained. The basal ration was found to be low in pantothenic acid and factor U. It has been demonstrated that additional factors other than the known members of the vitamin B complex are necessary for optimum growth of chicks fed the modified Goldberger diet. Various levels of animal tissues have been found to give good growth when used as supplements to the basal diet. There is no significant change in the blood picture of the chicks other than a reduced hemoglobin content of the blood when on the basal diet.