Inhibition of Aminotripeptidase.

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Abstract
A group of compounds known to possess antihistamine, local anesthetic, and anti-cholinesterase activities were observed to inhibit aminoexotripeptidase from several sources in concns. as low as 0.001 [image]. The inhibiting substances were Pyribenzamine, Benadryl, procaine, Pronestyl, cocaine, and eserine; diisopropylfluorophosphate and tetraethylpyrophosphate did not inhibit. The mechanism of the observed inhibition and its possible physiological significance is discussed.
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