MOUSE STRAIN DIFFERENCE IN MACROPHAGE ACTIVATION AND ANTITUMOR ACTIVITY INDUCED BY PROPIONIBACTERIUM-ACNES (ANAEROBIC CORYNEFORMS)

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (6) , 797-804
Abstract
Effect of P. acnes on macrophage activation and antitumor activity was examined in ddN and SL mice. C clearance was enhanced to the same extent by P. acnes treatment in both strains. The number of peritoneal macrophages increased to the same extent by P. acnes treatment in both strains. Adhesiveness of peritoneal macrophages, as demonstrated by inhibition of migration or an increase in spreading cells, was enhanced more efficiently in ddN than in SL mice by P. acnes treatment. Mice of both strains died in similar ways, when they were not pretreated. Treatment with P. acnes conferred antitumor activity of a higher degree in ddN than in SL mice. Peritoneal macrophages of ddN mice treated with P. acnes exhibited antitumor activity in in vivo neutralization tests. Strain difference in augmentation of antitumor activity by P. acnes is probably ascribed to distinct sensitivity of macrophage functions to the stimulative effect of P. acnes in the mouse strains.