A Model for the Study of Granulocyte Concentrate Preservation

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Abstract
An inexpensive model system for the study of granulocyte concentrate perservation was evaluated. Concentrates were collected from the same [human] donors within 1 h by manual and automated pheresis techniques. In both types of concentrates, phagocytosis, respiratory burst, microbial [Escherichia coli] killing and cell migration were normal within 4 h of collection. Granulocyte function defects induced by 24-48 h storage were similar in both types of concentrates; consequently, granulocyte concentrates collected as described here should serve as a useful model for the investigation of granulocyte concentrate preservation.