The Toxicity of Low‐molecular Triglycerides.

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Abstract
Summary.: The LD50 of low‐molecular triglycerides has been determined by intravenous injection into mice. The triglycerides were administered in the form of emulsions.The LD50 is found to be lowest in triisovalerin (82 ± 4 mg/kg) and to increase when the fatty acid chain contains less than 5 carbon atoms, reaching 1,600 ± 81 mg/kg in triacetin. With more than 5 carbon atoms in the fatty acid chain, LD50 rises successively and lies over 10,000 mg/kg for trinonylin, tricaprinin and triunde‐cylin.With lethal doses the symptom complex is somewhat variable, but generally includes respiratory arrest or respiratory embarrassment with a rapid onset, this being the probable cause of death.

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