Suppression ofTrypanosoma congolense, T. vivaxandT. bruceiinfection rates in tsetse flies maintained on goats immunized with uncoated forms of trypanosomes grownin vitro

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Abstract
Significant suppression in the incidence of cyclical development ofTrypanosonia congolense, T. vivaxandT. bruceioccurred inGlossina morsitans centralismaintained on goats immunized within vitro-propagated uncoated forms ofT. congolense, T. vivaxandT. brucei, respectively. This was observed when tsetse given aT. congolense-infected feed were subsequently maintained on uninfected immunized goats and also when uninfected tsetse were fed on immunized goats infected withT. congolense, T. vivaxandT. brucei. Suppression of infection rates in tsetse was trypanosome species specific, but was independent of the trypanosome stock used for immunization of goats. These findings were reflected in antibody responses to uncoated trypanosomes, as measured by immunofluorescence and the solid-phase immuno radiometric binding assay. Thus, antibody from goats immunized with uncoated trypano somes of one species exhibited minimal reactivity with uncoated forms of other species of trypanosomes, but showed high levels of activity with uncoated forms of the same or unrelated stocks of the same species. However, in view of the range of hosts upon which tsetse feed, it is open to question whether the use of a vaccine which suppresses trypanosome infection rates in tsetse would have any significant effect in the field.