The absorbtion and sputum penetration of doxycycline

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Abstract
The relation of doxycycline absorption and side-effects to concurrent administration with milk and water has been studied in a single-blind cross over study. Milk did not decrease absorption, but did lessen significantly nausea reported on administration with water. In a second group of patients, doxycycline achieved significantly higher serum (3.6 mg/l) and sputum (0.8 mg/l) concentrations than tetracycline (2.0 mg/l,0.2 mg/l). After allowing for the variation in serum concentration, sputum penetration by these antibiotics was not significantly different. Sputum purulence did not affect penetration of either antibiotic. Isolates of Streptococcus pneumoniae and Haemophilus influenzae from sputa received at the hospital laboratory were examined and their sensitivity to doxycycline and tetracycline compared to sputum penetration by these antimicrobial drugs.

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