ALFENTANIL: A STUDY OF ITS ANALGESIC ACTIVITY AND INTERACTIONS WITH MORPHINE IN THE MOUSE

Open Access
Publisher Website
Google Scholar
Abstract
Alfentanil has a short duration of action which did not markedly increase with increasing dose in mice It is approximately one-fourth as potent as fentanyl. Repeat injections gave reproducible analgesic effects but depression of respiratory rate increased when repeat injections were given on the basis of cessation of analgesic activity. Alfentanil appeared to reduce the analgesic effect of morphine given 30–60 min after alfentanil administration This has been demonstrated with injection of alfentanil 15min before, simultaneously with and 30 nun after morphine injection. There were no significant effects on depression of respiratory rate produced by morphine

This publication has 1 reference indexed in Scilit: